Hi,
Windows often changes monitor layout after a reboot, especially following updates. If your Remote Desktop session stops spanning correctly, check your local monitor arrangement first monitors must share a common edge. Then, save your RDP settings with “Use all monitors” enabled. Next, run mstsc.exe /l in Command Prompt to list monitor IDs. Edit your .rdp file and add the selectedmonitors setting manually, choosing the zero-based IDs for the monitors you want.
For example:
selectedmonitors:s:2,0
This places monitor 2 on the left in the remote session. If layouts change after updates, repeat the process.
If these not helps I suggest You can post your phenomenon in Microsoft feedback hub if it is more like a bug :
I hope this helps!