Dear Jeff-Seattle,
Thank you for using our service and for your inquiry about using PowerPoint Show (.ppsx) files on PowerPoint Online.
We would like to inform you that currently, the PowerPoint Show (.ppsx) format is not supported to open and automatically run a slideshow on the web version of PowerPoint (browser-based). When opening a .ppsx file on the web, it will display in the normal view or edit mode and will not automatically start the slideshow as it does on the desktop PowerPoint application.
We apologize for any inconvenience this may cause
As you know the Microsoft community is here to help with the information you need or issue you are facing regarding Office 365 products.
But since you have any concerns or changes that you want to make, you can always post your valuable suggestion on Microsoft Feedback portal. Ideas · Community
Best regards,
Dustin-TP-MSFT | Microsoft Community Support Specialist